解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric mucosa preparations. I...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90219-5
更新日期:1984-03-01 00:00:00
abstract::A pancreatic ductal carcinoma was established as a transplantable tumor line in an inbred strain of Syrian golden hamsters. Intracellular recordings of membrane potentials and input resistance were made from cultured cells obtained from the transplanted tumors using indwelling glass microelectrode. The mean value of t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90247-x
更新日期:1984-03-01 00:00:00
abstract::The distribution of the VIP containing structures was studied in the gut and in the paravertebral sympathetic ganglia of the quail and chick embryos by immunocytochemistry. In the gut, development of peptidergic nerves followed a craniocaudal gradient. Immunoreactive fibres were first visible in the oesophagus at day ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90206-7
更新日期:1984-03-01 00:00:00
abstract::Ethanol (ETOH) has been shown to have pronounced effects on reproductive endocrinology in humans as well as laboratory animals. We have studied the effects of ETOH on the hypothalamic-pituitary-luteinizing hormone (LH) axis, using the male rat as an animal model. In order to better understand the method by which ETOH ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90278-x
更新日期:1984-01-01 00:00:00
abstract::An immunohistochemical mapping study in the brain and upper spinal cord of the turtle Testudo hermanni Gmelin revealed a wide distribution of somatostatin perikarya and fibres. Within the telencephalon, somatostatin perikarya are present in the anterior olfactory nucleus, in the medial, dorsomedial and dorsal cortex, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90268-7
更新日期:1984-01-01 00:00:00
abstract::Dihydroergotoxine (DHET) is comprised of equal part of the mesylates of dihydroergocristine, dihydroergocornine and dihydroergocryptine. In the standard radioreceptor assays, DHET components displaced the CNS-receptor binding of [3H]-enkephalin (ENK) and [3H]thyrotropin releasing hormone (TRH). The inhibitory effect o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90050-0
更新日期:1984-01-01 00:00:00
abstract::CRF injected into the third cerebral ventricle (0.5-2.5 micrograms) caused dose-related reductions in fever induced in rabbits by IV administration of leukocytic pyrogen. Control injections of CRF when the same animals were afebrile did not alter normal body temperature. Intravenous injections of 5 and 20 micrograms C...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90051-2
更新日期:1984-01-01 00:00:00
abstract::Neurotensin-like immunoreactive neuronal perikarya, fibers and terminals in in the rat hypothalamus were investigated by light and electron microscopic immunocytochemistry. Distributional density and pattern of these elements were clarified. Fine structure of immunoreactive neuronal perikarya with respect to developme...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90270-5
更新日期:1984-01-01 00:00:00
abstract::The effects of alpha-neo-endorphin on mouse behavior were investigated by using a multi-dimensional behavioral analyser (Animex II) which classifies animal's movements into nine degrees. The intracerebral injection of alpha-neo-endorphin (30 micrograms) significantly decreased the 1/1, 1/2 and 1/4 sizes of movement (l...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90063-9
更新日期:1984-01-01 00:00:00
abstract::Recently two hypothalamic releasing factors have been isolated, sequenced and synthesized: corticotropin-releasing factor (CRF) from sheep and rat hypothalami; and growth hormone-releasing factor (GH-RF) from tumors in human pancreas (hpGH-RF) and from rat hypothalami (rhGH-RF). Their biological potencies were tested ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90282-1
更新日期:1984-01-01 00:00:00
abstract::We have developed a radioimmunoassay for synthetic dynorphin B, a novel opioid tridecapeptide, which shares a common precursor molecule with dynorphin1-17 (= dynorphin A) and the neo-endorphins. The levels of immunoreactivity towards this peptide in rat brain and pituitary show a pattern quantitatively and qualitative...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90083-9
更新日期:1983-11-01 00:00:00
abstract::Opiate binding sites in five brain regions were labeled with the mu and delta markers, 3H-morphine and 3H-[D-Ala2,D-leu5]enkephalin, respectively. The highest densities of both 3H-morphine and 3H-DADLE labeled sites are found in striatum and frontal cortex. Hypothalamus and midbrain contain predominantly 3H-morphine l...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90080-3
更新日期:1983-11-01 00:00:00
abstract::Recent reports suggest that arginine vasopressin (AVP) may be an endogenous antipyretic peptide and a mediator of febrile convulsions [10,12]. The spontaneously seizing Mongolian gerbil was used to investigate the thermoregulatory, behavioral and seizure modulatory effects of AVP. Injection of AVP (1.0 and 5.0 microgr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90070-0
更新日期:1983-11-01 00:00:00
abstract::Immunoreactive alpha-MSH was found in human skin and the skin of numerous other mammals. After hypophysectomy the concentration of alpha-MSH in rat skin showed little change suggesting that the pituitary is not the source of this MSH. In human skin the highest concentration was found in the epidermis and HPLC revealed...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90072-4
更新日期:1983-11-01 00:00:00
abstract::Inferences regarding biosynthesis of LHRH in rats are made from immunocytochemical studies using LHRH antisera with varied and specific binding requirements. Immunoreactive perikarya were observed with antisera that could bind putative large molecular weight precursors of LHRH. No cells were detected with an antiserum...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90096-7
更新日期:1983-11-01 00:00:00
abstract::Baboons received a 5-minute intravenous infusion of either saline or bombesin (BBS; 1-4 micrograms/kg) following 3 1/2 or 16 1/2 hours of food deprivation and were then allowed to eat for 30 minutes. Plasma insulin was significantly elevated following five minutes of BBS infusion, but there was no change of plasma glu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90019-0
更新日期:1983-09-01 00:00:00
abstract::Administration of the thiol reagent, cysteamine, reduced the somatostatin content (70-80%) in each of the discrete medullary nuclei assayed without altering the substance P content of the same nuclei. In contrast, capsaicin, the putative neurotoxin for primary sensory afferent neurons had no effect on the somatostatin...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90016-5
更新日期:1983-09-01 00:00:00
abstract::Opiate alkaloids and opioid peptides have been shown to suppress plasma LH and FSH levels via a naloxone sensitive mechanism in several species including man. Three subtypes of opiate receptors have been characterized: mu, delta and kappa. The present study was designed to investigate their role in gonadotropin releas...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90012-8
更新日期:1983-09-01 00:00:00
abstract::To confirm and extend the results of previous studies which demonstrated central cardiovascular effects of vasopressin in anesthetized rats, we determined blood pressure and heart rate changes for 30 minutes after intracerebroventricular injections of arginine vasopressin, arginine vasotocin and oxytocin in conscious ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90008-6
更新日期:1983-09-01 00:00:00
abstract::Neurotensin (NT) is a tridecapeptide (less than Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH). It has been suggested that the naturally occurring neurotensin in (Gln4)-NT and that it can be hydrolysed to (Glu4)-NT during extraction. The aim of the present study was to determine whether the neurotensin found ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90060-8
更新日期:1983-07-01 00:00:00
abstract::Neurotensin has been demonstrated to be analgesic in rodents. This study used intrathecal injection of neurotensin in unanesthetized mice to evaluate the effect of the peptide at the spinal level on unconditioned behavior. Intrathecal administration of neurotensin produced dose-related inhibition of locomotor activity...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90057-8
更新日期:1983-07-01 00:00:00
abstract::Cholecystokinin induces a reduction in exploratory behaviors which could reflect an underlying behavioral state of either satiety or malaise. To investigate these alternative hypotheses, the effects of CCK were compared to the effects of (a) consumption of an extra quantity of palatable food, of (b) bombesin at doses ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90040-2
更新日期:1983-07-01 00:00:00
abstract::Studies on the in vitro interaction of beta-endorphin with different biomembrane preparations, measured in terms of Ca2+ induced chlorotetracycline (CTC) fluorescence alterations indicate that beta-endorphin causes release of calcium ion from both synaptosomal and erythrocyte membrane stores but not from rat brain mit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90131-6
更新日期:1983-05-01 00:00:00
abstract::The effects of infusion of low concentrations of the synthetic opioid peptide D-Pro4-beta-casomorphin-5(deprolorphin) on electrical field responses in the in vitro hippocampal slice preparation of mice were investigated. Deprolorphin (0.01-10 microM) causes a large enhancement of the population spike (PS) and appearan...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90133-x
更新日期:1983-05-01 00:00:00
abstract::Apamin is a neurotoxic octadecapeptide from bee venom, which has been shown to inhibit the non-adrenergic, non-cholinergic inhibitory innervation of the smooth muscle of the gut. Since vasoactive intestinal polypeptide (VIP) has been proposed as a possible inhibitory neurotransmitter, the effect of apamin on the recep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90102-x
更新日期:1983-03-01 00:00:00
abstract::Histidyl-proline diketopiperazine (cyclo(His-Pro), a metabolite of the neuropeptide thyrotropin releasing hormone, has been shown to possess intrinsic biological activities. The binding of this peptide to various tissue particulate preparations was investigated. While the peptide showed no apparent binding to particul...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90172-9
更新日期:1983-01-01 00:00:00
abstract::Dermorphin, injected intracerebroventricularly (ICV) to rats, provokes, like to morphine, an inhibition of intestinal propulsion linearly related to the log of the administered doses (in the range from 0.06 to 0.56 micrograms/rat), but it is 143 times more active than morphine. Naloxone, ICV or IP, antagonizes dermorp...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90165-1
更新日期:1983-01-01 00:00:00
abstract::The effects of arginine vasotocin (AVT), 4-6 ng/kg, on renal function and plasma prolactin (PRL) were determined in conscious American foxhounds undergoing a water diuresis. Intravenous AVT produced an antidiuresis, kaliuresis and inconsistent natriuresis, independently of changes in GFR, blood pressure, heart rate an...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90062-6
更新日期:1982-11-01 00:00:00
abstract::A new series of analogues of the potent opiate-like peptides dermorphins (mainly tetra- and pentapeptides) were synthesized in order to better evaluate the structure-activity relationships. Relative potencies were referred to dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), the prototype of this class of frog skin pe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90009-2
更新日期:1982-09-01 00:00:00
abstract::The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel. Four-week old chicks were maintained in a thermoneutral environment of 23-24 degrees C. After food was removed for a 24 hr interv...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90008-0
更新日期:1982-09-01 00:00:00
abstract::Immunohistochemical studies were conducted on sections of cat hypothalamus in order to determine the distribution of neurons containing alpha-melanocyte stimulating hormone and beta-endorphin immunoreactivity. A large number of neurons in the arcuate nucleus were stained after incubation of sections with antisera to e...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90167-x
更新日期:1982-07-01 00:00:00
abstract::The use of protein A- and IgG-conjugated colloidal gold staining methods for the immuno-localisation of peptide hormones and neurotransmitters at light- and electron microscope level are described and discussed. Bright-field and dark-ground illumination modes have been used to visualise the gold-labelled antigenic sit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90086-9
更新日期:1982-05-01 00:00:00
abstract::Most small peptide hormones and neurotransmitters are highly flexible, conformationally labile molecules in aqueous and other environments. Thus efforts to determine the relationships between conformational properties of these peptides in aqueous and other solvents and their biological activities at membrane receptors...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90095-x
更新日期:1982-05-01 00:00:00
abstract::Gastrin/CCK peptides in extracts from bovine and porcine pituitary have been characterized by Sephadex gel filtration, reverse phase liquid chromatography and a CCK radioimmunoassay (RIA) which detects both CCK and gastrin [4]. Porcine pituitary extracts contain a small amount of two peptides with chromatographic beha...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90121-8
更新日期:1982-05-01 00:00:00
abstract::Adrenocorticotropic Hormone (ACTH), Melanocyte-Stimulating Hormone (MSH), and related peptides have been shown to have several neurogenic effects: alteration of cerebral protein synthesis, RNA synthesis, protein phosphorylation, and neurotransmitter turnover. Furthermore, there appears to be an ACTH containing circuit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90101-2
更新日期:1982-05-01 00:00:00
abstract::The rat central and peripheral nervous system contains a widespread distribution of BPP-like immunoreactive neurons. Some of these neurons coexist with a catecholamine, probably mostly NE. This peptide appears to be releaseable by nerve stimulation. Catecholamine releasing agents such as reserpine do not appear to dep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90128-0
更新日期:1982-05-01 00:00:00
abstract::The levels of rat plasma beta-endorphin-like immunoreactivity following a 30 min exposure to (1) an unfamiliar operant chamber, (2) an unfamiliar operant chamber providing a VI-5 second schedule of 3 mA, 1 sec footshocks, or (3) a familiar chamber providing no shocks, but previously paired with unavoidable shocks were...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90052-3
更新日期:1982-03-01 00:00:00
abstract::We have attempted to demonstrate a pancreatic secretory response to intraduodenal amino acids in the anesthetized cat. In four cats stimulated with supramaximal doses of secretin, protein concentrations in pancreatic juice were measured after intraduodenal bolus injection of various amino acids, IV CCK, or electrical ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90040-7
更新日期:1982-03-01 00:00:00
abstract::The biological activities of alpha-MSH des-acetyl MSH, gamma-MSH and LPH37-58 were compared using the Anolis rate method of bioassay. Dose-response data showed LPH37-58 to be equipotent with alpha-MSH, but des-acetyl MSH and gamma-MSH were found to be much less active. The effect of LPH37-58 was additive to that of al...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90134-6
更新日期:1982-01-01 00:00:00
abstract::Dermorphins are potent opiate-like peptides isolated from the skin of some species of frogs. They are characterized by the presence of a D-amino acid residue, which is crucial for bioactivity. A number of analogues were prepared in order to evaluate the structure-activity relationships. The syntheses were accomplished...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80117-9
更新日期:1981-10-01 00:00:00